Recombinant coagulation factors were the eighth largest selling class of biological products, with total sales in 2005 estimated at $2.2 billion.

Coagulation factors are a group of protein substances (factors I through XIII) contained in plasma which act in concert to bring about blood clotting. When some of these proteins are deficient or missing, the result can be mild to severe bleeding.

Recombinant coagulation factors are bioengineered proteins produced to replicate naturally occurring coagulation factors and are used to stop bleeding, primarily in people who have Hemophilia A or Hemophilia B.

Among the leading recombinant coagulation factors are: